Some of the world's best companies have a significant presence here.
Fortune 100 companies like Amazon.com, Microsoft, Barnes & Noble, and Intuit, among others, all operate in the Greater Reno-Tahoe area. Below is a list of Fortune 100 companies that have a significant presence in the Greater Reno-Tahoe area:
| 1 Wal-Mart | 32 State Farm | 70 Sysco |
| 3 General Motors | 38 Wachovia | 71 Cisco Systems |
| 6 General Electric | 40 Walgreen | 72 Johnson Controls |
| 8 Citigroup | 41 Wells Fargo | 73 Honeywell International |
| 9 Bank of America | 44 Microsoft | 75 American Express |
| 10 AT&T | 46 United Parcel Service | 80 Alcoa |
| 17 Verizon Communications | 47 Pfizer | 82 New York Life |
| 19 Cardinal Health | 48 Lowe's | 83 Coca-Cola |
| 21 Morgan Stanley | 50 Caterpillar | 91 Macy's |
| 22 Home Depot | 55 Safeway | 92 Delphi |
| 27 Boeing | 57 Lockheed Martin | 94 Liberty Mutual |
| 28 AmerisourceBergen | 58 Sprint Nextel | 97 Washington Mutual |
| 29 Costco | 59 PepsiCo | 99 Mass Mutual |
| 30 Merril Lynch | 66 Best Buy | |
| 31 Target | 68 FedEx |
Source: Fortune Magazine (2008)
